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phenobarbital will decrease the extent or effect of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.phenobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with strong CYP3A4 inducers; these medicines lower

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